Madison County Vacations & Trips from $322

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Your Madison County Vacation

When adventure calls, answer it with a tailor-made vacation package to Madison County. Wherever you're headed and whatever you have planned, prepare to experience a destination with plenty to offer. Want to know where to go on your trip to Madison County? Fredericktown is a leading city you won't want to miss. When it's time to stop dreaming and start traveling, Expedia will help turn your Madison County vacation into reality.

Top destinations in Madison County

A clear stream with large rocks and pebbles.

Fredericktown

Fredericktown

The Latest Madison County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel

$322
per person
Oct 1 - Oct 4
found 6 hours ago
Roundtrip flight included
Chicago (ORD) to Cape Girardeau (CGI)
9.4/10 Exceptional! (105 reviews)
The Riverview

The Riverview

$803
per person
Sep 21 - Sep 23
found 1 day ago
Roundtrip flight included
Monroe (MLU) to Cape Girardeau (CGI)
9.4/10 Exceptional! (638 reviews)
University Inn of Carbondale by Hotel O

University Inn of Carbondale by Hotel O

$794
per person
Sep 14 - Sep 16
found 1 day ago
Roundtrip non-stop flight included
Monroe (MLU) to Cape Girardeau (CGI)
5.8/10 (401 reviews)
it was being constructed!

Reviewed on Aug 11, 2026

Hampton Inn Carbondale

Hampton Inn Carbondale

$804
per person
Sep 21 - Sep 23
found 1 day ago
Roundtrip flight included
Monroe (MLU) to Cape Girardeau (CGI)
8.4/10 Very Good! (664 reviews)
The staff is always very nice. The room is always clean. The facilities looks good. Parking is nice. Breakfast is good.

Reviewed on Aug 11, 2026

Home2 Suites by Hilton Carbondale

Home2 Suites by Hilton Carbondale

$825
per person
Sep 21 - Sep 23
found 1 day ago
Roundtrip flight included
Monroe (MLU) to Cape Girardeau (CGI)
8.8/10 Excellent! (569 reviews)
Helpful and friendly staff. Decent breakfast. Joe and crew very accomodating.

Reviewed on Aug 10, 2026

Find the Best Madison County Vacation Packages

Madison County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Top Sights
Millstream Gardens Conservation Area, Silver Mine Recreation Area and Millstream Gardens Conservation Area

Madison County Hotel Deals

Madison Inn Lodge

Madison Inn Lodge

730 Plaza Drive Fredericktown MO
Fully refundableReserve now, pay when you stay
$88 nightly
$96 total
Aug 13 - Aug 14
Total with taxes and fees
7.6/10 Good! (306 reviews)
"Room wasn’t all that clean. Had some questionable stains, kind of dusty, bath room needed a good deep clean. No bugs in the bed so I suppose that’s a huge plus! It was cheap for one night. Said it had breakfast in the AM, we weren’t that brave to try it."

Reviewed on Aug 9, 2026

Madison Inn Lodge
St Francis River: The Blue Yurt and Hot Tub

St Francis River: The Blue Yurt and Hot Tub

Fredericktown MO
$199 nightly
$215 total
Aug 17 - Aug 18
Total with taxes and fees
St Francis River: The Blue Yurt and Hot Tub
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
$58 nightly
$63 total
Aug 19 - Aug 20
Total with taxes and fees
Baymont Inn and Suites by Wyndham Farmington, MO
See all 215 properties in Madison County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Madison County attractions

A river flowing through a rocky landscape with trees and hills in the background.

Millstream Gardens Conservation Area

9.2/10 (7 reviews)
Explore the great outdoors at Millstream Gardens Conservation Area, a lovely green space in Fredericktown. While you're in the area, wander around the natural setting.
See properties
A rocky shoreline with a calm body of water and a forested cliff in the background.

Silver Mine Recreation Area

8.8/10 (6 reviews)
Explore the great outdoors at Silver Mine Recreation Area, a lovely green space in Fredericktown. While you're in the area, wander around the natural setting.
See properties

Madison County Courthouse

7.4/10 (6 reviews)
After visiting Madison County Courthouse, make a plan to see the other sights and activities in Fredericktown. While you're in the area, wander around the natural setting.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.